1.¬†Far Infrared Therapy¬†Promotes Nerve Repair following End-to-End Neurorrhaphy in¬†Rat Models of Sciatic Nerve Injury.
This study employed a rat model of sciatic nerve injury to investigate the effects of postoperative low-power¬†far–infrared¬†(FIR) radiation¬†therapy¬†on nerve repair following end-to-end neurorrhaphy. The rat models were divided into the following 3 groups: (1) nerve injury without FIR biostimulation (NI/sham group); (2) nerve injury with FIR biostimulation (NI/FIR group); and (3) noninjured controls (normal group). Walking-track analysis results showed that the NI/FIR group exhibited significantly higher sciatic functional indices at 8 weeks after surgery (P < 0.05) compared with the NI/sham group. The decreased expression of CD4 and CD8 in the NI/FIR group indicated that FIR irradiation modulated the inflammatory process during recovery. Compared with the NI/sham group, the NI/FIR group exhibited a significant reduction in muscle atrophy (P < 0.05). Furthermore, histomorphometric assessment indicated that the nerves regenerated more rapidly in the NI/FIR group than in the NI/sham group; furthermore, the NI/FIR group regenerated neural tissue over a larger area, as well as nerve fibers of greater diameter and with thicker myelin sheaths.
Functional recovery, inflammatory response, muscular reinnervation, and histomorphometric assessment all indicated that FIR radiation¬†therapy¬†can accelerate nerve repair following end-to-end neurorrhaphy of the sciatic nerve.